Inter-individual variation in DNA methylation is largely restricted to tissue-specific differentially methylated regions in maize
نویسندگان
چکیده
منابع مشابه
A convenient method to generate methylated and un-methylated control DNA in methylation studies
Methylated and un-methylated control DNA is an important part of DNA methylation studies. Although human and mouse DNA methylation control sets are commercially available, in case of methylation studies on other species such as animals, plants, and bacteria, control sets need to be prepared. In this paper a simple method of generating methylated and un-methylated control DNA is described. Whole...
متن کاملProbe Lasso: A novel method to rope in differentially methylated regions with 450K DNA methylation data
The speed and resolution at which we can scour the genome for DNA methylation changes has improved immeasurably in the last 10years and the advent of the Illumina 450K BeadChip has made epigenome-wide association studies (EWAS) a reality. The resulting datasets are conveniently formatted to allow easy alignment of significant hits to genes and genetic features, however; methods that parse signi...
متن کاملDNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) in mouse promoter regions demonstrating tissue-specific gene expression.
DNA methylation constitutes an important epigenetic regulation mechanism in many eukaryotes, although the extent of DNA methylation in the regulation of gene expression in the mammalian genome is poorly understood. We developed D-REAM, a genome-wide DNA methylation analysis method for tissue-dependent and differentially methylated region (T-DMR) profiling with restriction tag-mediated amplifica...
متن کاملUsing the charm package to estimate DNA methylation levels and find differentially methylated regions
The Bioconductor package charm can be used to analyze DNA methylation data generated using McrBC fractionation and two-color Nimblegen microarrays. It is customized for use with the from the custom CHARM microarray [1], but can also be applied to many other Nimblegen designs. Functions include: • Quality control • Finding suitable control probes for normalization • Percentage methylation estima...
متن کاملDNA methylation at differentially methylated regions of imprinted genes is resistant to developmental programming by maternal nutrition
The nutritional environment in which the mammalian fetus or infant develop is recognized as influencing the risk of chronic diseases, such as type 2 diabetes and hypertension, in a phenomenon that has become known as developmental programming. The late onset of such diseases in response to earlier transient experiences has led to the suggestion that developmental programming may have an epigene...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Plant Biology
سال: 2017
ISSN: 1471-2229
DOI: 10.1186/s12870-017-0997-3